Udindo wa chitetezo cha mthupi mwa kubereka kwa munthu ndipamwamba kwambiri. Asayansi asonyeza kuti pafupifupi munthu mmodzi pa anthu asanu aliwonse amene ali ndi matenda osabereka osadziŵika amakhala ndi vuto ndi chitetezo cha mthupi. Chimodzi mwa zinthu zomwe zimagwirizanitsidwa ndi chitetezo cha m'thupi, chomwe chingayambitse kusabereka, ndiko kugwiritsidwa ntchito kwa matupi a antispermal.
Thupi limeneli limagwira nawo ntchito yogwiritsira ntchito magemetes (gametes), osaloleza spermatozoa kuti alowe mu chipolopolo cha dzira. Njira yomwe amachitira izi sizimvetsetsa bwino, koma zakhala zikuonekeratu kuti ma antibodieswa amachititsa kuti acrosomal ayankhe ma maselo a spermatozoon, omwe amachititsa kuti zikhale zofunikira kuti pakhale umuna wabwino. Ngati mmodzi mwa abwenziwo, amuna kapena akazi, ali ndi matupi a antispermic, ndiye kuti mazira amakhala oipitsitsa kusiyana ndi omwe alibe anthu oterewa, omwe amachepetsa kuperewera kwa mankhwala osabereka kudzera mu mavitamini. Ngati ACAT ikulephera kuchitidwa ndi njira zowonongeka, njira yowonjezera ya awiriwa ndi kukhazikitsa spermatozoa mu dzira (ICSI).
Njira zodziwira anti-antibodies mwa akazi
Oimira abambo omwe ali ofooka, ma antibodies antisperm amatsimikiziridwa mu ntchentche ya chiberekero komanso m'magazi a m'magazi. Ndiloyenera kuyesa kupezeka kwa ma antibodies amenewa mwa mabanja omwe akukonzekera IVF.
Kaŵirikaŵiri pakukhazikitsidwa kwa ma antibodies antisperm, njira zomwe zimagwiritsidwa ntchito potengera ma antibodies omwe amatsutsana ndi ma antigen a membrane amagwiritsidwa ntchito. Izi zikuphatikizapo njira monga:
- Kuyezetsa mgwirizano wa spermatozoa ndi mitsempha ya chibelekero, kapena postcoital. Tiyenera kukumbukira kuti chimodzi mwa zifukwa zomwe zimayambitsa vuto la postcoital yolakwika ndi kuti pali ACAT mu umuna, ndiko kuti, vuto limagwirizana ndi munthu, osati ku chiberekero. Komabe, kawirikawiri zimatheka kusunga kuphatikiza kwa zifukwa zazimayi ndi amuna. Mayeso a Postcoital sali odalirika kwambiri poyesa kusabereka ndipo kwa iye chiwerengero cha deta yonyenga ndi chapamwamba kwambiri. Ichi ndichifukwa chake sichigwiritsidwa ntchito payekha, pokhapokha pamodzi ndi chidziwitso kuchokera ku kafukufuku pa ACAT;
- MAR-mayeso. Imeneyi ndi njira yomwe imakuthandizani kuti muzindikire nambala ya spermatozoa yomwe imagwirizanitsidwa ndi magulu a antibiotic IgA ndi IgG, komanso imathandizanso kudziwika ndi ma antibodies antisperm m'madzi otere monga chiberekero, spermoplasm, plasma. Mayesowa amadziwika padziko lonse ngati chiwerengero cha matenda a ACAT, ali ndi mphamvu zowonongeka komanso zapamwamba;
- Mayeso a latex agglutination ndi mayeso atsopano omwe sanagwidwe ndi ACAT. Mayesowa ndi njira yeniyeni yodziwira ACAT mu zakumwa zachilengedwe, monga madzi a m'magazi, nyemba, chiberekero cha chiberekero. Ali ndi kutengeka kwakukulu. Makhalidwe a antibodies omwe angawoneke pogwiritsa ntchito njirayi sagwirizana nthawi zonse ndi ma antibodies omwe amadziwika ndi mayesero awiri oyambirirawo, choncho amasonkhana pamodzi kuti apeze zotsatira zowonjezereka;
- ELISA (enzyme immunoassay) - nthawi zambiri amagwiritsidwa ntchito kufufuza ACAT m'magazi a m'magazi. Ikuonedwa kuti ndi imodzi mwa njira zowonjezereka zogwiritsira ntchito ACAT. Makhalidwe akuluakulu a ACAT, omwe amatsimikiziridwa ndi njira imeneyi m'magazi a magazi mwa amayi, sangagwirizane ndi kuwonongeka kwa mimba.
Njira zochiritsira
Mankhwala a maanja amene apezeka ndi kuchuluka kwa ACAT akhoza kuchitidwa m'njira zosiyanasiyana, malingana ndi zotsatira za kufufuza. Choyamba, nthawi zambiri, njira yogwiritsira ntchito, yomwe ndi kondomu, imagwiritsidwa ntchito kwa nthawi ya miyezi 2-5 kapena mkatikatikati, pamene kondomu sinagwiritsidwe ntchito pokhapokha masiku omwe ali ovomerezeka pakuoneka mimba.
Kuchepetsa kuchuluka kwa umuna kulowa mu thupi la mayi kumapangitsa kuchepa kwa kaphatikizidwe ka ma antibodies ndipo kumawonjezera mwayi wokhala ndi mimba.
Panthawi imodzimodziyo, mankhwala amatha kuperekedwa, omwe amachepetsa mamasukidwe akayendedwe a chiberekero ndipo amaletsa kaphatikizidwe ka ACAT muzokwatirana. Ngati njira zowonongeka siziwathandiza, ndiye kuti amasamukira ku ISKI.