Monica sanafune kumanga ntchito. Ankafuna kukhala woweruza wabwino, ndipo kuti apite ku yunivesite, adagwiritsa ntchito chitsanzo ngati ali ndi zaka 16. Koma pasanapite nthawi, iye ankakonda moyo wa anthu ndipo anasankha kupitiliza kukondweretsa, ndikusiya maloto ake oti akhale loya.
Monica anali ndi zilankhulo zambiri, monga Chingerezi, Chifalansa, ndithudi Chiitaliya ndi Chisipanishi pang'ono.
Ntchito yaikulu yomwe adaipeza mu 1992, pamene adapatsidwa mwayi wokhala mkwatibwi wa Dracula mu filimuyo "Dracula". Pambuyo pa ntchitoyi, adalandira zopereka zatsopano kuchokera ku studio zojambula zamakono ku Ulaya ndi ku America. Mphoto ya Monica ikubwera pambuyo pa filimu "Apartment" mu 1996 ndipo adalandira mphoto "Cesar". Panthawi yomwe filimuyi inkajambula filimuyi, Monica anadziwana ndi Vincent Cassel yemwe anali mwamuna wake wam'tsogolo. Anayambanso kuyang'ana mu filimu yakuchita ku France Doberman.
Kuchokera mu 1997 mpaka 1998, Monica anagwirizanitsa pazithunzi zisanu ndi ziwiri: "Kusokonezeka maganizo," "Tchimo loipa", "Kodi Mukufuna Ine", "Chikhumbo", "Sipadzakhalanso Tchuthi", "Ponena za Amene Amakonda", "Kuyanjana". Koma pa Bellucci sanasiye, adalandira zatsopano, koma sanafulumize kuti aziwonekera mu filimu yonse yomwe adaperekedwa. Monica anali wovuta kwambiri ponena za maudindo omwe anapatsidwa. Iye anasankha maudindo okha omwe angamuwonetse iye akuchita talente.
Mwamunayo amadziwika kuti ndi chitsanzo komanso chojambula, Monica akupezeka pamagazini owala. Bellucci potsiriza anamuwonetsera talente yake mu kanema "Malena", kutenga mitima ya onse owona ndi otsutsa. Kuima pa mafilimu a mtundu umodzi Monica sanafune, ataganiza kuti achite filimu mu filimu yaikulu "Chisoni cha Khristu".
Bellucci samaima mpaka tsopano ndipo akuwombera mu mafilimu osiyanasiyana, pokhala wochita masewera oyamba ku Hollywood.
Monica nayenso anakhala nkhope ya kampani ya "Royal Velvet" Oriflame ndi nkhope ya maluwa a Dolce & Gabbana.